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John 5:40

Mission impossible

CREATION

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1 mm

1 mm

1 mm

Imagine one of those granules was coloured RED and you were asked to find it. It would most definitely be MISSION IMPOSSIBLE.

10
89

100,

000,000,000,000,000,000,000,000,000,

000,000,000,000,000,000,000,000,000,

000,000,000,000,000,000,000,000,000,

000,000

Back on Page 5 we saw how many large sugar granules (1mm x 1mm x 1mm) it would take to fill our 93 billion light-years-wide universe. It was

Protein is essential for life. Without it, human life could not continue. It should therefore not surprise us to know that the word PROTEIN means ‘PRIME IMPORTANCE’ - ‘HOLDING FIRST PLACE’.

Protein is made up of a chain of amino acids. Amino acids come in two orientations - LEFT HANDED and RIGHT HANDED. This is known as CHIRALITY. The word CHIRALITY is derived from the Greek χείρ (cheir), meaning ‘the hand’

R
R

Left handed

Right handed

This can be explained using SCRABBLE letters. Imagine the Scrabble box was full of letters in RIGHT and LEFT HANDED forms, in equal amounts, but you can only make words using the LEFT HANDED type. The game is going to be much more difficult! Twice as difficult in fact.

The amino acids found in proteins almost always come in the LEFT HANDED form

Dr Doug Axe

Dr. Douglas Axe is a Chemical Engineer who held Postdoctoral and Research Scientist Positions at Cambridge University. He asked the question -

The amino acids in the protein chain are ‘glued’ together by peptide bonds. Just imagine the Scrabble letters glued together with Sticky, the world’s best glue.

C
A
R

The parallel would be a meaningful English sentence built with 100 scrabble letters, held together with our Sticky glue.

Axe took into account 3 issues - Bonding, Chirality and Sequence

BONDING - You need 99 peptide bonds between the 100 amino acids. The odds of getting a peptide bond is 50%. The probability of building a chain of one hundred amino acids in which all linkages involve peptide bonds is roughly 1 chance in 10^30.

CHIRALITY - You need 100 left-handed amino acids. The odds of getting a left-handed amino acid is 50%. The probability of getting at random only L–amino acids in a peptide chain one hundred amino acids long is roughly 1 chance in 10^30.

SEQUENCE - You need to choose the correct amino acid for each of the 100 links. The odds of getting the right one are 1 in 20 because there are 20 different types of amino acid. The odds of getting a functional sequence is 1 in 10^65.

The final probability of getting a functional protein composed of 100 amino acids is 1 in 10^125 which is ...

10
125

Which simply means you have a billion, billion, billion, billion universes, and you have to find that one RED sugar granule!!

Mission Impossible!

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“What are the odds of building a protein composed of a functional chain of 100 amino acids, by chance?”